Research Updates
Browse recent clinical, scientific, and educational developments.
Treatment response to systemic therapies in pediatric-onset versus adult-onset psoriasis: a longitudinal real-world study.
Psoriasis may present with onset in childhood or adulthood, reflecting distinct clinical patterns. Whether treatment response differs between these groups remains unclear, particularly across systemic therapies in real-world settings.
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Accurate assessment of plantar loading, including shear forces, is crucial for understanding foot pathologies such as dactylitis in psoriatic arthritis (PsA). Existing devices predominantly measure plantar pressures, neglecting important shear stresses which may initiate dactylitis.
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Tocilizumab, a humanized monoclonal antibody targeting the interleukin-6 receptor, is widely used in immune-mediated diseases, yet its real-world safety in pediatric populations remains insufficiently characterized. This retrospective pharmacovigilance study analyzed adverse event (AE) reports fr...
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Development and assessment of an artificial intelligence-based tool for scoring lesion severity in generalized pustular psoriasis clinical images.
Generalized pustular psoriasis (GPP) is a rare, chronic, systemic inflammatory disease characterized by unpredictable chronic symptoms and periods of flaring. Assessing GPP severity is important for defining treatment goals and evaluating treatment responses, yet the rarity of the disease and the...
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Psychosocial adjustment to stigma among young adults with chronic visible skin disease.
Living with a stigmatizing skin disease may hinder normative development during emerging adulthood. The present study aimed to examine indirect effects of internalized stigma in the relationship between social stigma and psychosocial adjustment among young adults with visible chronic skin diseases.
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Deucravacitinib in concomitant psoriasis vulgaris and bullous pemphigoid: A case of sustained dual disease control.
Deucravacitinib in concomitant psoriasis vulgaris and bullous pemphigoid: A case of sustained dual disease control.
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Meta-Analysis of Long-Term Major Adverse Cardiovascular Events of Different Biologics in Psoriatic Patients.
Psoriasis is a chronic immune-mediated inflammatory disease associated with systemic inflammation and an increased risk of cardiovascular events. Although biologic therapies have transformed psoriasis treatment, the long-term impact of different biologic classes on major adverse cardiovascular ev...
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Editor's Highlights-December 2026.
The effects of climate change, unequal access to biologic therapies, and the limited representation of Indigenous communities and diverse skin tones in educational materials underscore an important point: dermatology does not operate independently of social and environmental factors. The five pap...
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Targeting Cannabinoid 1 Receptor in Macrophages Alleviates Psoriatic Skin Inflammation Through the AUF1-NLRP3 Axis.
Psoriasis is a chronic inflammatory skin disease associated with systemic metabolic dysregulation; however, the molecular pathways linking metabolic signaling to skin inflammation remain poorly understood. Here, we identify cannabinoid 1 receptor (CB1R) in macrophages as a key immunometabolic reg...
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Targeting Macrophage STING O-GlcNAcylation via Small-Molecule Allosteric Modulation for Psoriasis Therapy.
STING undergoes distinct post-translational modifications in autoimmune disorders, particularly in psoriasis. However, selectively targeting these disease-associated STING modifications remains a major therapeutic challenge.
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Genetic and tissue-level analyses prioritize HDL-associated apolipoprotein M in psoriasis.
Dysregulated lipid metabolism is associated with psoriasis, but the HDL-related molecular traits linked to psoriatic disease remain incompletely defined. We integrated epidemiological, Mendelian randomization (MR), and multi-omics analyses to investigate HDL-C and HDL-associated molecular traits ...
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Biologic therapies targeting interleukin IL-17, IL-23 and IL-12/23 have substantially improved outcomes in patients with moderate-to-severe psoriasis. In real-world settings, treatment effectiveness depends not only on drug efficacy but also on patient adherence, which is essential for the approp...
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Errors in Incidence Rates and Other Numbers in Study of Paradoxical Eczema in Patients Receiving Biologics for Psoriasis.
Errors in Incidence Rates and Other Numbers in Study of Paradoxical Eczema in Patients Receiving Biologics for Psoriasis.
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Callicarpa nudiflora-Derived Extracellular Vesicle-Based Hydrogel Loaded with Apremilast for Enhanced Therapy of Psoriasis.
Apremilast (APST) is an effective medication for psoriasis, but its clinical application is limited by its exclusive availability as an oral tablet formulation and the associated systemic adverse effects. Hydrogel-based transdermal delivery offers a promising alternative for localized APST admini...
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Refractory Psoriatic Lesions in Japanese Patients Before and After Switching Biologics.
Biologics can improve disease control in patients with psoriasis vulgaris (PsO) and psoriatic arthritis (PsA); however, refractory regions may persist despite biologic therapy. This study aimed to evaluate refractory anatomical regions in patients with PsO and PsA who underwent biologic switching.
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Temporomandibular disorders in women with psoriatic arthritis by history of psoriasis: a cross-sectional study.
Temporomandibular joint involvement in psoriatic arthritis may result in impaired jaw function and reduced oral health-related quality of life. Patients with PsA have generally been analyzed as a single group regardless of psoriasis history, despite a reported association between psoriasis and TM...
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Quercetin confers protection against psoriasis by inhibiting AKR1B10-mediated glycolytic reprogramming in keratinocytes.
The anti-psoriatic effect of quercetin has been observed. However, the involved mechanism remains poorly explored.
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Real-world evidence on long-term effectiveness and safety of oral Janus kinase (JAK) inhibitors in atopic dermatitis (AD) remains limited. This study evaluated sustained long-term clinical and patient-reported disease control and safety during continuous treatment with upadacitinib 30 mg or ...
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K17 hi Hair Follicle Cells Orchestrate Psoriatic Inflammation Through S100A1-Dependent Signaling.
Psoriasis is a chronic inflammatory skin disease with frequent and refractory scalp involvement, but the mechanisms underlying regional susceptibility remain unclear. To define the role of hair follicle cell (HFC) subsets in psoriatic inflammation and uncover their pathogenic mechanisms.
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OX40 Ligand/OX40 Axis as the Inflammatory Prequel in Atopic Dermatitis: A Narrative Review.
Atopic dermatitis is a complex and relapsing inflammatory skin disease attributed to skin barrier dysfunction and immune dysregulation. Because of the heterogeneous and unpredictable nature of the disease, moderate to severe atopic dermatitis remains challenging to treat, with a continued need fo...
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Rezpegaldesleukin and Regulatory T Cell Restoration in Immune-Mediated Skin Diseases.
Inflammatory skin diseases such as atopic dermatitis (AD), psoriasis, and alopecia areata (AA) are characterized by immune dysregulation involving impaired regulatory T cell (Treg) function and persistent activation of effector inflammatory pathways. Current targeted therapies largely suppress do...
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Psoriasis is a persistent, immune-driven inflammatory skin disorder impacting an estimated 125 million individuals globally. The pursuit of effective and safe treatments at affordable costs remains an ongoing challenge.
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Myocardial dysfunction in psoriasis: Interpretation and clinical considerations.
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Variable Phenotypes and Spesolimab Responses in Familial Pustular Psoriasis with IL36RN and CARD14 Mutations.
Variable Phenotypes and Spesolimab Responses in Familial Pustular Psoriasis with IL36RN and CARD14 Mutations.
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Infection risk in psoriasis: not all biologics are the same.
Infection risk in psoriasis: not all biologics are the same.
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GLP-1 receptor agonists in psoriasis management.
Psoriasis is a systemic chronic inflammatory skin disease associated with musculoskeletal, cardiovascular, metabolic, psychiatric, and gastrointestinal comorbidities. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 RAs have e...
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Construction of risk prediction models for psoriasis based on 45 dietary nutrients using machine learning and SHAP analysis.
To develop and validate a machine learning model to predict the risk of psoriasis based on 45 dietary nutrients. 12,749 participants from the National Health and Nutrition Examination Survey from 2009-2014 were included and their demographic, lifestyle, health status, and dietary nutrient-related...
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To compare the within-study discriminatory characteristics of established inflammatory back pain (IBP) criteria sets and individual items in predefined groups of patients with axial psoriatic arthritis (axPsA), non-psoriatic axial spondyloarthritis (axSpA), and chronic mechanical low back pain (c...
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Longitudinal fatigue outcomes and prediction in inflammatory arthritis: a real-world digital cohort study.
Fatigue is a burdensome symptom in inflammatory arthritis (IA), yet meaningful longitudinal change remains poorly characterized in real-world settings. To characterize fatigue trajectories, quantify clinically meaningful improvement/worsening, and identify baseline predictors of fatigue outcomes ...
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Woronoff's Halo and a Phenotypic Shift from Psoriasis to Eczema.
Woronoff's Halo and a Phenotypic Shift from Psoriasis to Eczema.
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Real-World Effectiveness of Biologic Therapy in Patients with Psoriasis: Metabolic Comorbidities and Treatment Outcomes.
Psoriasis is a chronic systemic inflammatory disease, frequently associated with metabolic comorbidities that may influence therapeutic outcomes. Real-world evidence on the effectiveness of biologic therapy in this complex clinical context remains limited.
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Prospective reflectance confocal microscopy monitoring in dupilumab-treated atopic dermatitis.
Dupilumab provides substantial clinical benefit in moderate-to-severe atopic dermatitis, but whether clinical improvement is accompanied by microstructural resolution on reflectance confocal microscopy (RCM) remains unclear. To describe baseline clinical and RCM findings, evaluate longitudinal cl...
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Durable remission of sinonasal mucosal melanoma despite early ICI discontinuation and risankizumab treatment for irAEs.
Sinonasal mucosal melanoma (SNMM) is a rare and aggressive malignancy with few effective treatments. Unlike cutaneous melanoma, responses to immune checkpoint inhibitors (ICIs) in mucosal subtypes are typically modest.
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Effectiveness and Safety of Non-Medical Switch From Ustekinumab Originator to Biosimilar AVT04 in Patients With Plaque Psoriasis: A Monocentric Real-Life Study.
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Curcuma longa rhizomes and Cannabis sativa leaves are traditionally combined in Thai topical remedies using cottonseed oil. However, the pharmacological basis and dermal delivery of this combination remain unclear.
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The itch-dominant phenotype of atopic dermatitis carries a disproportionate psychosocial burden.
The itch-dominant phenotype of atopic dermatitis carries a disproportionate psychosocial burden.
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Development of a Conceptual Disease Model of Atopic Dermatitis Using Data from the Phase 3 ARCADIA 1 Trial.
Patients with atopic dermatitis (AD) often experience severe skin disease, intense itching, sleep disturbance, and impaired quality of life (QoL). This study aimed to generate a clinically credible, data-driven conceptual disease model (CDM) of AD using baseline data from the phase 3 ARCADIA 1 tr...
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The therapeutic landscape for moderate-to-severe psoriasis has expanded rapidly with biologics and small molecules, increasing the complexity of clinical decision-making. Although large language models (LLMs) may support medical information synthesis, their reliability in high-stakes dermatologic...
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SPR-UPLC-QTOF/MS-GNPS-Guided Discovery of Hypermonol J as a Novel Tumor Necrosis Factor-Binding Small-Molecule Lead for Inflammatory Storm Intervention.
SPR-UPLC-QTOF/MS-GNPS-Guided Discovery of Hypermonol J as a Novel Tumor Necrosis Factor-Binding Small-Molecule Lead for Inflammatory Storm Intervention.
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Reactions to Acrylates in Dentistry and Related Factors - The First Croatian Survey Study on Reactions to Acrylates in Dentistry.
Our aim was to examine the potential impact of acrylate exposure and the influence of other associated factors on skin and mucosal changes/lesions among dental professionals and students. In this cross-sectional field study, we used a questionaire to survey 136 participants-including dentists, de...
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Waist circumference provides improved cardiometabolic discrimination compared with body mass index in psoriatic disease: discrimination and reclassification analyses.
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Real-World Use of Abrocitinib for Moderate-to-Severe Atopic Dermatitis in the United States Based on Electronic Health Records and Administrative Claims.
Real-World Use of Abrocitinib for Moderate-to-Severe Atopic Dermatitis in the United States Based on Electronic Health Records and Administrative Claims.
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Clinical practice guideline for psoriasis management in Latin America.
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Behçet's-Like Syndrome Associated With Psoriasis, Lichen Sclerosus and Variant in NF-κB1.
Behçet's-Like Syndrome Associated With Psoriasis, Lichen Sclerosus and Variant in NF-κB1.
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Corrigendum to "Choline kinase beta promotes psoriasis pathogenesis by regulating sphingolipid metabolism and activating the PI3K/Akt/GSK3β signaling pathway" [Biochim. Biophys Acta (BBA) - Mol.
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Discontinuation and Re-Initiation of Biologic Therapy in Psoriasis: Lessons From Real-World Practice.
Discontinuation and Re-Initiation of Biologic Therapy in Psoriasis: Lessons From Real-World Practice.
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Cardiometabolic Associations of Dermatological Treatments. Part I: Systemic Therapies.
Cardiometabolic Associations of Dermatological Treatments. Part I: Systemic Therapies.
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Cardiac dysfunction in psoriasis: Methodologic considerations for cross-sectional findings.
Cardiac dysfunction in psoriasis: Methodologic considerations for cross-sectional findings.
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Discovery of a novel CDK8 inhibitor as dual suppressor of NF-κB-driven inflammation and promoter of Treg differentiation for psoriasis treatment.
Discovery of a novel CDK8 inhibitor as dual suppressor of NF-κB-driven inflammation and promoter of Treg differentiation for psoriasis treatment.
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Reduced prevalence of rhinitis and eczema but not wheezing in native-born children from cross-border marriages.
Reduced prevalence of rhinitis and eczema but not wheezing in native-born children from cross-border marriages.
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